Tietz Textbook of Clinical Chemistry and Molecular Diagnostics [edited by] Nader Rifai, Andrea Rita Horvath, Carl T. Wittwer

Includes bibliographical references and index

Section I. Basics of Laboratory Medicine: Clinical chemistry and molecular diagnostics -- Statistical methodologies in laboratory medicine: analytical and clinical evaluation of laboratory tests -- Quality management in the medical laboratory -- Specimen collection and processing -- Preanalytical variation and preexamination processes -- Quality control of the analytical examination process -- Biological variation -- Establishment and use of reference intervals -- Evidence-based laboratory medicine -- Biobanking -- Laboratory support of pharmaceutical, in vitro diagnostics and epidemiologic studies -- Section II. Analytical Techniques and Applications: Principles of basic techniques and laboratory safety -- Optical techniques -- Electrochemistry and chemical sensors -- Chromatography -- Mass spectrometry -- Sample preparation for mass spectrometry applications -- Mass spectrometry applications in infectious disease and pathogens identification -- Development and validation of small molecule analytes by liquid chromatography-tandem mass spectrometry -- Proteomics -- Enzyme and rate analysis -- Immunochemical techniques -- Microfabrication and microfluidics and their application in clinical diagnostics -- Cytometry -- Automation in the clinical laboratory -- Point-of-care testing --

Section III. Analytes: Amino acids, peptides, and proteins -- Serum enzymes -- Enzymes of the red blood cell -- Tumor markers -- Kidney function tests -- Carbohydrates -- Lipids, lipoproteins, apolipoproteins, and other cardiovascular risk -- Electrolytes and blood gases -- Hormones -- Vitamins and trace elements -- Hemoglobin, iron, bilirubin -- Porphyrins and the porphyrias -- Therapeutic drugs and their management -- Clinical toxicology -- Toxic elements -- Body fluids -- Section IV. Molecular Diagnostics: Principles of molecular biology -- Genomes and variants -- Nucleic acid isolation -- Nucleic acid techniques -- Molecular microbiology -- Genetics -- Solid tumor genomics -- Genetic aspects of hematopoietic malignancies -- Circulating tumor cells and circulating tumor DNA -- Circulating nucleic acids for prenatal diagnostics -- Pharmacogenetics -- Identity testing --

Section V. Pathophysiology: Nutrition: laboratory and clinical aspects -- Diabetes mellitus -- Cardiac function -- Kidney disease -- Disorders of water, electrolytes, and acid-base metabolism -- Liver disease -- Gastric, pancreatic, and intestinal function -- Monoamine-producing tumors -- Bone and mineral metabolism -- Pituitary function and pathophysiology -- Adrenal cortex -- Thyroid disorders -- Reproductive endocrinology and related disorders -- Pregnancy and its disorders -- Newborn screening and inborn errors of metabolism -- Section VI. Hematology and Coagulation: Hemostasis -- Red blood cell morphology and indices with clinical chemistry interface -- Automated hematology --

Section VII. Microbiology: Bacteriology -- Antimicrobial susceptibility testing -- Mycobacteriology -- Mycology -- Parasitology -- Virology -- Section VIII. Transfusion Medicine: Blood groups, pretransfusion testing, and red blood cell transfusion -- Blood components, blood donor screening, and transfusion reactions -- Appendix: Reference information for the clinical laboratory